What question did this study set out to answer?

To summarize the major classes and molecular mechanisms of histone deacetylases and histone deacetylase inhibitors, emphasizing intrinsic and extrinsic apoptotic pathways in hepatocellular carcinoma.

January 1, 2021Open Access

Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic Alterations of Histone Deacetylases (HDACs) in Hepatocellular Carcinoma.

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Authors

MSMasumeh Sanaei FKFraidoon Kavoosi

Discussion

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Overview

Literature review demonstrates that histone deacetylase inhibitors trigger apoptosis in hepatocellular carcinoma cells, suggesting targeted epigenetic therapy can suppress tumor growth.

Key Points

To summarize the major classes and molecular mechanisms of histone deacetylases and histone deacetylase inhibitors, emphasizing intrinsic and extrinsic apoptotic pathways in hepatocellular carcinoma.
Conducted an electronic literature search across PubMed, ISI Web of Science, and Scopus databases.
Synthesized molecular evidence on histone deacetylase dysregulation, chromatin remodeling, and inhibitor-mediated apoptosis in liver cancer cells.
Aberrant histone deacetylation by dysregulated histone deacetylases suppresses tumor-suppressor gene expression and drives hepatocellular carcinoma progression.
Inhibition of histone deacetylases reverses abnormal deacetylation, curbing cancer cell proliferation and stimulating cell death through both mitochondrial (intrinsic) and cytoplasmic (extrinsic) apoptotic pathways.

Cite This Study

Sanaei et al. (2021) studied this question.

synapsesocial.com/papers/6aade1fc31f0686ca400dca0 https://doi.org/10.22037/ijpr.2021.115105.15197

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January 1, 2021Open Access

Histone Deacetylase Inhibitors, Intrinsic and Extrinsic Apoptotic Pathways, and Epigenetic Alterations of Histone Deacetylases (HDACs) in Hepatocellular Carcinoma.

View Full Paper

Ask AI

Bookmark

Authors

MSMasumeh Sanaei FKFraidoon Kavoosi

Discussion

Member takes

Overview

Literature review demonstrates that histone deacetylase inhibitors trigger apoptosis in hepatocellular carcinoma cells, suggesting targeted epigenetic therapy can suppress tumor growth.

Key Points

To summarize the major classes and molecular mechanisms of histone deacetylases and histone deacetylase inhibitors, emphasizing intrinsic and extrinsic apoptotic pathways in hepatocellular carcinoma.
Conducted an electronic literature search across PubMed, ISI Web of Science, and Scopus databases.
Synthesized molecular evidence on histone deacetylase dysregulation, chromatin remodeling, and inhibitor-mediated apoptosis in liver cancer cells.
Aberrant histone deacetylation by dysregulated histone deacetylases suppresses tumor-suppressor gene expression and drives hepatocellular carcinoma progression.
Inhibition of histone deacetylases reverses abnormal deacetylation, curbing cancer cell proliferation and stimulating cell death through both mitochondrial (intrinsic) and cytoplasmic (extrinsic) apoptotic pathways.

Cite This Study

Sanaei et al. (2021) studied this question.

synapsesocial.com/papers/6aade1fc31f0686ca400dca0 https://doi.org/10.22037/ijpr.2021.115105.15197

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