The NAD+ stack, optimized: A multi-target strategy to support healthy aging

The NAD+ stack, optimized: A multi-target strategy to support healthy aging Research has identified key mechanisms driving aging and actionable targets for promoting longevity. A promising strategy is to preserve the cell’s ability to produce energy, repair DNA, and stress resilience, with nicotinamide adenine dinucleotide (NAD+) playing a central role. Here, Dr. Rebecca Crews presents a multi-target approach to support healthy aging. Decades of research have uncovered key mechanisms driving the aging process, identifying actionable targets to support longevity. One of the most promising strategies is preserving the cell’s capacity for energy production, DNA repair, and stress resilience. Central to all of these processes is nicotinamide adenine dinucleotide (NAD+), a coenzyme that fuels hundreds of metabolic reactions, including mitochondrial ATP production and sirtuin-mediated cellular maintenance.