Correlation of Testosterone levels in healthy men with Fasting Glucose, Insulin Resistance HOMA IR and Vitamin D. A Clinical Study

Background: Testosterone, the primary male sex hormone, is essential for reproductive health and plays a significant role in various physiological functions, including metabolic processes. Recent studies suggest that testosterone levels may influence metabolic parameters such as fasting glucose, insulin resistance, and vitamin D status in men. Aim: This clinical study aims to investigate the correlations between testosterone levels and the following metabolic parameters: fasting glucose, insulin resistance (HOMA-IR), and vitamin D levels in healthy men. Materials and Methods: A cohort of 100 healthy men was recruited for this study and allocated into two groups: group 1(aged 18-65) and group 2(aged ≥ 65). Serum testosterone, fasting glucose, HOMA-IR, and vitamin D levels were measured. Pearson correlation analysis was employed to assess the relationships between testosterone and the aforementioned metabolic parameters. Statistical significance was determined using appropriate tests, with a p-value of <0.05 considered significant. Results: Findings of this study indicated a significant decrease in testosterone levels with advancing age (p<0.05). In addition, the results demonstrated no significant correlation (p>0.05) between testosterone concentrations and insulin levels, fasting glucose levels, or HOMA-IR scores. Conclusion: Within the limits of this study, no association was observed between testosterone and the examined parameters. These results suggest that further research could inform therapeutic strategies for managing low testosterone and its associated metabolic disorders in men.