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September 10, 2025Molecular Cancer Research

Myeloid-Derived Suppressor Cells: Orchestrators of Tumor Immune Evasion and Therapeutic Vulnerabilities

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Authors

ZWZeshi WangXDXiaoping DuXXX. Xing

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Overview

This review uncovers how myeloid-derived suppressor cells facilitate immune suppression in tumors, suggesting novel therapeutic strategies.

Key Points

  • Myeloid-derived suppressor cells play a significant role in tumor immune evasion, impairing T cell function and promoting tumor progression.
  • Therapy approaches targeting myeloid-derived suppressor cells include depletion and functional inhibition, enhancing immune responses.
  • Current strategies exploit MDSCs' immunosuppressive actions to heighten the efficacy of existing immunotherapies against tumors.
  • Research indicates that combining MDSC-targeted therapies with checkpoint inhibitors could significantly improve patient outcomes.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1ae7754b1d3bfb60e69a4https://doi.org/10.1158/1541-7786.mcr-25-0251
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Myeloid-Derived Suppressor Cells in Tumor Immunotherapy2011 · 32 citations
  2. 2Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion2024 · 165 citations
  3. 3Myeloid-Derived Suppressor Cells in Cancer: Metabolic Reprogramming, Immune Crosstalk, and Therapeutic Targeting2026
  4. 4Targeting MDSCs in cancer: emerging immunotherapeutic and metabolic strategies.2026
  5. 5Myeloid‐Derived Suppressor Cells: Immunoregulatory Roles and Therapeutic Prospects in Immune‐Mediated Hematological Disorders2026