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January 1, 2013Journal for ImmunoTherapy of CancerOpen Access

Myeloid derived suppressor cells – a new therapeutic target in the treatment of cancer

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Authors

RWRobert WesolowskiJMJoseph MarkowitzWCWilliam E. Carson

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Overview

Narrative review reveals mechanisms of myeloid-derived suppressor cell-mediated immune evasion in cancer, highlighting therapeutic inhibition strategies.

Key Points

  • To review the biological mechanisms by which myeloid-derived suppressor cells inhibit host antitumor immunity and assess clinical strategies for targeting them in cancer therapy.
  • Narrative review summarizing preclinical and clinical literature on myeloid-derived suppressor cell biology in cancer, inflammation, and infection.
  • Evaluated the pathways driving cell expansion, immunosuppression, and tumor progression, alongside emerging therapeutic interventions.
  • Tumor-secreted growth factors expand myeloid-derived suppressor cells, which inhibit antitumor responses via arginase 1 production, reactive oxygen species, nitric oxide, and immunosuppressive cytokines.
  • Myeloid-derived suppressor cells facilitate a permissive microenvironment for tumor survival and directly contribute to angiogenesis and tumor tissue invasion.

Cite This Study

Wesolowski et al. (2013) studied this question.

synapsesocial.com/papers/6a7bb77524f98b6d3fc29164https://doi.org/10.1186/2051-1426-1-10
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