Synthesis, Antifungal and Anti-Tubercular Activity Evaluation of Series of Imidazo [2,1-b]1,3,4-Thiadiazole Derivatives

Antimicrobial drugs are the greatest contribution to the 20th century to therapeutics. The methodology indicates and characterizes various aspects like melting point, solubility, TLC, and IR. The experimental work comprises of various methods like preparation of 2-amino-5-trifluromethyl,1,3,4, thiadiazole preparation. According to this, we synthesized a series of sixteen derivatives of selected compound. The synthesized compounds were evaluated for antimicrobial and antifungal activity by disc diffusion method. The results of the antimicrobial screening studies clearly shows moderate to mild antimicrobial activity.