Clinical evaluation of a plant-based supplement on hair, skin, nail health, and psychological well-being: A 90-day observational study

Objectives: The study aimed to evaluate the efficacy and safety of a plant-based supplement containing biotin (10,000 mcg), collagen peptides, vitamin C, glycoproteins, and amino acids in improving hair, skin, and nail health over a 90-day period. The supplement was designed to address common esthetic concerns such as hair thinning, brittle nails, and early signs of skin aging through a natural, multi-functional approach. Materials and Methods: A total of 30 participants (18 males, 12 females; mean age 36.9 ± 9.2 years) presenting with dermatological concerns, including hair loss, dull skin, brittle nails, and early signs of aging, were enrolled in a prospective, open-label, single-arm observational study. Participants received two tablets daily of the plant-based supplement for 90 days. Assessments were conducted at baseline, day 30, day 60, and day 90 using a combination of clinical evaluations, instrumental diagnostics (phototrichogram, digital skin analysis), and participant-reported feedback. Key parameters included hair fall reduction (through a 60-s hair comb test), hair density and growth rate, skin hydration, pigmentation, wrinkle depth, elasticity, pore size, and nail growth. Results: The study demonstrated significant and progressive improvements across all parameters. Hair fall was reduced by 90% on day 30, 95% on day 60, and 99% on day 90. Hair density improved by 30 units over the study period, and hair growth rate increased by 20%. Hair texture improved by 61% by day 90. Nail growth increased by 40%, with enhanced appearance and strength. Skin analysis showed a 31.11% increase in hydration, a 31.15% decrease in pigmentation, an 18.12% improvement in elasticity, and a 19.19% reduction in wrinkle length. Pore volume was reduced by 31%. No adverse effects were reported, and participants noted visible improvements in overall appearance and well-being. Conclusion: The 90-day intervention with the plant-based supplement resulted in substantial improvements in hair, skin, and nail health. The findings support its use as a safe, well-tolerated, and effective nutraceutical for esthetic enhancement and healthy aging. The product’s natural formulation offers a promising alternative to conventional treatments, with added psychosocial benefits such as improved self-image and quality of life.