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September 10, 2025Frontiers in ImmunologyOpen Access

Maternal immunity and African swine fever virus: understanding the limits of passive protection

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Observational analysis shows maternal immunity impacts ASF virus outcomes in piglets, suggesting limitations in passive protection.

Maternal immunity fails to protect neonatal piglets from lethal ASF virus infection, with all challenged piglets succumbing.
Serology confirmed antibodies were present in piglets of immune sows, but many became seronegative post-infection.
Neonatal piglets receiving immunoglobulin transfer did not survive the ASF virus challenge, indicating insufficient passive immunity.
Antibody levels in unchallenged piglets were stable for at least 60 days but depleted following ASFV exposure.

Friedrichs et al. (2025) studied this question.

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