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September 10, 2025Meditsinskiy sovet = Medical CouncilOpen Access

Evaluation of the effectiveness of targeted screening to detect familial hypercholesterolemia in children

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Universal screening demonstrated 100% sensitivity and specificity, outperforming targeted methods.
Targeted screening only identified 5 out of 15 familial hypercholesterolemia cases, with a sensitivity of 33.3%.
The combined screening approach also achieved 100% sensitivity, indicating high diagnostic accuracy.
Data supports expanded screening programs for familial hypercholesterolemia to prevent cardiovascular diseases in children.

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Implication

Targeted, universal, and combined screening methods reveal differences in sensitivity and specificity for detecting familial hypercholesterolemia in children.

Cite This Study

Pupykina et al. (2025) studied this question.

synapsesocial.com/papers/68c1afd354b1d3bfb60e81c0 https://doi.org/10.21518/ms2025-284

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Implication

Targeted, universal, and combined screening methods reveal differences in sensitivity and specificity for detecting familial hypercholesterolemia in children.

Evaluation of the effectiveness of targeted screening to detect familial hypercholesterolemia in children

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Discussion

Implication

Cite This Study

Evaluation of the effectiveness of targeted screening to detect familial hypercholesterolemia in children

Key Points

Discussion

Implication

Cite This Study

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