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September 10, 2025EndocrinesOpen Access

Neuroendocrinological Aspects of a Tailored Hormonal Contraception

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Hormonal contraceptives influence brain function by modulating neurotransmitters like serotonin and dopamine.
Different estrogenic and progestin components affect emotional regulation pathways, impacting mood and desire.
Evidence suggests that estradiol-based formulations with anti-androgenic progestins may improve neuroendocrine profiles.
Understanding neuroendocrine mechanisms may lead to more personalized contraceptive options for women with mood disorders.

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Narrative review uncovers the role of neuroendocrinology in hormonal contraception choices, suggesting personalized approaches for women.

Battipaglia et al. (2025) studied this question.

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