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September 10, 2025ChemistrySelect

Synthesis, Characterization, Computational Studies and In Vitro Biological Effects of Novel Pyrazoles, Pyridazines, Thiazoles Containing a Quinazoline Scaffold

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Authors

AAAisha A. AlsfoukPrincess Nourah bint Abdulrahman UniversityIOIsmail M. M. OthmanAl-Azhar UniversityHNHamdi M. D. NasrAl-Azhar University

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Overview

Novel pyrazole derivatives exhibited antimicrobial activity in microorganisms, suggesting potential therapeutic applications.

Key Points

  • Pyrazole analogue 5b demonstrated significant antimicrobial potency against several bacteria, showing levels comparable to amoxicillin.
  • The derivatives showed effectiveness against fungi A. niger and C. albicans, although less potent than ketoconazole.
  • Inhibition studies revealed that derivatives 5a and 5b suppressed S. aureus DNA gyrase effectively, outperforming reference standards.
  • Computational docking indicated strong interactions of pyrazoles with DNA gyrase, supporting their potential as therapeutic agents.

Cite This Study

Alsfouk et al. (2025) studied this question.

synapsesocial.com/papers/68c1b18554b1d3bfb60e8659https://doi.org/10.1002/slct.202501583
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