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September 27, 2025Future Journal of Pharmaceutical SciencesOpen Access

Synthesis, antimicrobial evaluation, and in silico studies of some novel hydrazinylquinoline and pyrazoline derivatives as potential antimicrobial agents

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Authors

RBRabiu BakoNONatasha OctoberAIAbdullahi Idris

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Overview

Research shows new hydrazone and pyrazoline derivatives exhibit antimicrobial activity in vitro, suggesting potential as effective agents against resistant bacteria.

Key Points

  • The newly synthesized compounds show strong antimicrobial activity, particularly against Gram-negative bacteria and some Gram-positive strains.
  • MIC values of 12.5 mg/mL were found for E. coli and S. typhi, indicating significant potency compared to traditional drugs.
  • Molecular docking studies reveal strong binding affinities of the derivatives to target enzymes, surpassing standard drugs' performance.
  • In silico analysis confirms that all compounds follow Lipinski’s rule of five, indicating favorable drug-like properties.

Cite This Study

Bako et al. (2025) studied this question.

synapsesocial.com/papers/68d7be66eebfec0fc5237c86https://doi.org/10.1186/s43094-025-00882-8
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Also Consider

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  1. 1Design and synthesis of pyrazole–heteroaryl arylhydrazone schiff base hybrids with antimicrobial and docking evaluation2026
  2. 2Synthesis, Characterization, Computational Studies and In Vitro Biological Effects of Novel Pyrazoles, Pyridazines, Thiazoles Containing a Quinazoline Scaffold2025
  3. 3Synthesis, and Computational Insights Into Quinoline Hydrazide Derivatives as Potential Antimicrobial Agents2025
  4. 4Novel Benzimidazole based Hydrazide-hydrazone Compounds: Synthesis, Characterization and Antimicrobial Assessment2024
  5. 5Synthesis, Antimicrobial Activities, and Docking Simulations of Novel Hybrid Molecules Based on Bis‐Thiazole Linked to a Pyridine Core2026