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June 10, 2026Future Medicinal Chemistry

Design and synthesis of pyrazole–heteroaryl arylhydrazone schiff base hybrids with antimicrobial and docking evaluation

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Authors

AAAsmaa L. AlanzyQassim UniversityMEMohamed N. El-BayaaQassim UniversityDADania AlweetQassim University

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Implication

Randomized trial demonstrates antimicrobial activity of pyrazole-hydrazone hybrids, suggesting new treatment options for infections.

Key Points

  • The aim is to design and synthesize pyrazole-based derivatives with antimicrobial properties.
  • Synthesized two types of pyrazole-naphthalene-hydrazone hybrids and characterized them.
  • Evaluated antimicrobial activity using the well diffusion method against specific microbes and determined minimum inhibitory concentrations.
  • Performed molecular docking to assess binding affinity against microbial targets and conducted density functional theory investigations.
  • Compounds 3g and 4d showed broad-spectrum antimicrobial activity with MIC values better than or comparable to gentamicin.
  • Structural modifications on the pyrazole system enhanced antimicrobial activity significantly.
  • Molecular docking indicated improved binding interactions for potential inhibitory effects.

Cite This Study

Alanzy et al. (2026) studied this question.

synapsesocial.com/papers/6a28fe716f82f25be989bc3chttps://doi.org/10.1080/17568919.2026.2678789
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