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September 10, 2025Animal DiseasesOpen Access

Maternal and lactogenic immunity in gestating sows induced by adenoviruses expressing mucosal immunogens derived from porcine epidemic diarrhea virus

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Authors

NBNamphueng ButkhotTKThotsapol KaewchomphunuchPRPimploy Rattanaamnuaychai

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Overview

Randomized controlled trial found adenovirus-based vaccines boost maternal and lactogenic immunity in sows, indicating enhanced protection for piglets.

Key Points

  • rAd-based vaccines expressing OmpH significantly elevated neutralizing antibodies in sows, providing vital immunity to piglets.
  • The rAd. PEDVSME-CTB led to the strongest PEDV-specific IgG response, highlighting its potential for protective immunity.
  • All rAd-based vaccines surpass control in transferring maternal antibodies into colostrum, supporting piglet health.
  • Notably, IgG showed a stronger correlation with neutralization effectiveness than IgA, emphasizing the role of immunoglobulin types.

Cite This Study

Butkhot et al. (2025) studied this question.

synapsesocial.com/papers/68c1b18b54b1d3bfb60e8794https://doi.org/10.1186/s44149-025-00185-8
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Also Consider

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  1. 1Adenovirus-vectored African Swine Fever Virus Antigens Cocktail Is Not Protective against Virulent Arm07 Isolate in Eurasian Wild Boar2020 · 65 citations
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  3. 3Comparison of Porcine Epidemic Diarrhea Viruses from Germany and the United States, 20142014 · 136 citations
  4. 4Evolutionary and genotypic analyses of global porcine epidemic diarrhea virus strains2018 · 148 citations
  5. 5Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus–Host Interactions2022 · 119 citations