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July 2, 2026Veterinary SciencesOpen Access

Overcoming Antigenic Drift in PEDV: Broadly Protective Antigen Design and sIgA-Driven Lactogenic Immunity

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Authors

QZQiao-Qiao ZhangHZH Steve ZhangLZLan‐Lan Zheng

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Overview

Review highlights advances in vaccine design and mucosal immunity for improved PEDV protection in pigs, suggesting implications for enteric coronaviruses.

Key Points

  • This review aims to address the challenges of PEDV vaccination by exploring antigenic drift and optimizing maternal immunity.
  • Review mechanisms of PEDV evolution and maternal immunity.
  • Discuss current vaccine limitations and innovations.
  • Propose an integrated framework for broadly protective vaccines based on mucosal-targeted strategies.
  • Current vaccines primarily induce systemic IgG, inadequate for lactogenic immunity.
  • Antigenic variation hinders vaccine effectiveness.
  • Proposed framework aims to enhance sIgA production and maternal vaccine efficacy.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a4600a29ed1343031310b51https://doi.org/10.3390/vetsci13070647
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal and lactogenic immunity in gestating sows induced by adenoviruses expressing mucosal immunogens derived from porcine epidemic diarrhea virus2025
  2. 2Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus2026
  3. 3Developing Next-Generation Live Attenuated Vaccines for Porcine Epidemic Diarrhea Using Reverse Genetic Techniques2024 · 15 citations
  4. 4Dynamic Antibody Responses in Porcine Epidemic Diarrhea Virus‐Infected Pigs and Correlation of Prepartum Serum, Oral Swabs, and Rectal Swabs With Postpartum Colostral IgA and IgG in Sows2026
  5. 5Development of a vaccine based on mRNA assembly of PEDV virus-like particle2026