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September 10, 2025Tropical Medicine and HealthOpen Access

Comparative performance of Kato–Katz, POC-CCA and real-time PCR in detecting Schistosoma mansoni infection at different endemicity settings in northwest Ethiopia: a cross-sectional study

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Authors

GAGetaneh AlemuENEndalkachew NibretAMAbaineh Munshea

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Overview

Cross-sectional study evaluates POC-CCA, Kato–Katz, and RT-PCR in detecting schistosoma mansoni infection, suggesting POC-CCA for field use.

Key Points

  • POC-CCA showed the highest sensitivity (93.4–100%) across all transmission levels.
  • Kato–Katz detected a lower prevalence (33.4%) with reduced sensitivity, especially in low endemic areas.
  • RT-PCR demonstrated high sensitivity (up to 97.2%) but declining specificity with increased endemicity.
  • POC-CCA is recommended for SCH control in Ethiopia due to its feasibility compared to RT-PCR.

Cite This Study

Alemu et al. (2025) studied this question.

synapsesocial.com/papers/68c1b18b54b1d3bfb60e8848https://doi.org/10.1186/s41182-025-00777-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic Performance and Discordance of Kato–Katz Method, POC-CCA Test, and PCR in Detecting Schistosoma mansoni in a Low-Prevalence South African Setting2026
  2. 2Assessment of Schistosoma mansoni and soil-transmitted helminth infections and the diagnostic performance of the circulating cathodic antigen test among schoolchildren in Tulla district, Sidama region, Southern Ethiopia2025
  3. 3Kato-Katz versus Urine Circulating Cathodic Antigen for the Diagnosis of Schistosoma mansoni in Preschool- aged children in Homabay County- Kenya2024
  4. 4Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis2022 · 16 citations
  5. 5Diagnostic Accuracy and Applicability of a PCR System for the Detection of Schistosoma mansoni DNA in Human Urine Samples from an Endemic Area2012 · 86 citations