Observational analysis shows improved signal-to-background ratio using pseudo-HiLo in PV interneurons, indicating enhanced voltage imaging capabilities.
We utilize pseudo-HiLo (pHiLo) for voltage imaging in awake mice expressing Voltron2552 in parvalbumin (PV) interneurons in the somatosensory cortex. We demonstrate increased signal-to-background ratio using pHiLo compared to traditional widefield neural recording.
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Speed et al. (2025) studied this question.
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