Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Open MedicineOpen Access

Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization

View Full Paper
Ask AI
Bookmark
Share

Authors

QLQian LiuLMLing‐bing MengTQTianqi Qi

Discussion

Loading...

Member takes

Overview

Mendelian randomization reveals causal links between cerebrospinal fluid metabolites and cognitive performance, suggesting treatment pathways.

Key Points

  • Cerebrospinal fluid metabolites influence brain atrophy and cognitive function, with 30 metabolites showing causal associations.
  • Analysis highlighted butyrate's strong correlation with cortical surface area and bilirubin's with cortical thickness.
  • This two-sample Mendelian randomization utilized genome-wide association data from 689 individuals for metabolites and 257,841 for cognition.
  • Findings suggest that targeting cerebrospinal fluid metabolites may open avenues for therapies in neurodegenerative diseases.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19354b1d3bfb60e8cdfhttps://doi.org/10.1515/med-2025-1237
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combined Proteomic and Metabolomic Profiling of Serum Reveals Association of the Complement System with Obesity and Identifies Novel Markers of Body Fat Mass Changes2011 · 222 citations
  2. 2Mechanisms of Ischemic Neuroprotection by Acetyl‐l‐carnitine2005 · 123 citations
  3. 3The genetic architecture of the human cerebral cortex2018 · 42 citations
  4. 4The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny2000 · 809 citations