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November 28, 2025Endocrinology Diabetes & MetabolismOpen Access

The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis

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Authors

FLFang LiangTXTiegang XiaoBWBing Wang

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Overview

Mendelian randomisation analysis shows 24 metabolites in cerebrospinal fluid correlate with NAFLD, indicating potential therapeutic strategies and diagnostic biomarkers.

Key Points

  • Cerebrospinal fluid metabolites show significant associations with non‐alcoholic fatty liver disease.
  • Twenty-four metabolites were identified, including amino acids and uracil, affecting NAFLD development.
  • Mendelian randomisation analysis employed genome-wide association study data for causal inference.
  • Findings highlight the brain‐liver axis’s role, suggesting a basis for therapeutic strategies and biomarkers.

Cite This Study

Liang et al. (2025) studied this question.

synapsesocial.com/papers/6928f113a65b730b9ea79fedhttps://doi.org/10.1002/edm2.70088
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