Key result
Elevated CHG index is linked to ~16% higher odds of new-onset hypertension.
Why the study?
New biomarkers are needed to optimize risk stratification for hypertension, and the relationship between the novel cholesterol, high-density lipoprotein, and glucose (CHG) index and incident hypertension across different sex and glycemic statuses required investigation.
Is the cholesterol-HDL-glucose (CHG) index associated with the incidence of new-onset hypertension across different sexes and glycemic statuses?
Cohort (n=6,555)
Is the cholesterol-HDL-glucose (CHG) index associated with the incidence of new-onset hypertension across different sexes and glycemic statuses?
Answers are grounded in this paper and cite their sources.
An elevated CHG index demonstrates a positive linear relationship with new-onset hypertension and significantly improves risk prediction beyond basic models across various sex and glycemic subgroups.
BACKGROUND: Hypertension is a major global public health issue, and the continuous search for new biomarkers to optimize risk stratification is crucial. This study aims to investigate the relationship between a novel metabolic disorder diagnostic tool-cholesterol, high-density lipoprotein, and glucose (CHG) index-and the incidence of hypertension in populations with different sexes and glycemic statuses. METHODS: This study utilized 9 years of follow-up data from the China Health and Retirement Longitudinal Study. Logistic regression models were employed to examine the association between the CHG index and new-onset hypertension across different sex and glycemic statuses. Additionally, the net reclassification improvement and integrated discrimination improvement indices were calculated to estimate the additional predictive value beyond the basic model. RESULTS: A total of 6555 participants were included in the study. A significant association between CHG index and new-onset hypertension was observed in the total, male, female, prediabetic, and diabetic populations, with adjusted OR (95% CI) of 1.16 (1.10-1.24), 1.23 (1.12-1.36), 1.12 (1.02-1.22), 1.14 (1.01-1.29), and 1.19 (1.03-1.36) respectively. Restricted Cubic Spline (RCS) analysis revealed a positive linear relationship between the CHG index and new-onset hypertension. The addition of either the CHG index or the Triglyceride-Glucose (TyG) index significantly improved the predictive performance of the basic model for hypertension. CONCLUSIONS: An elevated CHG index is significantly associated with new-onset hypertension.
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He et al. (2026) conducted a cohort in New-onset hypertension (n=6,555). Cholesterol-HDL-Glucose (CHG) index was evaluated on New-onset hypertension (OR 1.16, 95% CI 1.10-1.24). An elevated Cholesterol-HDL-Glucose (CHG) index was significantly associated with new-onset hypertension in the total population (adjusted OR 1.16; 95% CI 1.10-1.24).
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