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This is a Literature Review study.

September 10, 2025TheranosticsOpen Access

The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment

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This review highlights the role of cellular senescence and SASP in the tumor microenvironment, suggesting implications for immunotherapy.

Cellular senescence impacts the tumor microenvironment and may promote tumor progression through dysfunctional immune cells.
Senescent CD8+ and CD4+ T cells show impaired immunosuppression and resistance to immunotherapy, complicating treatment outcomes.
Research explores strategies targeting senescence, including clearing senescent cells and inhibiting the tumor-promoting SASP.
While promising approaches exist, none are in clinical practice yet, highlighting the need for ongoing research.

Shi et al. (2025) studied this question.

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