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March 15, 2026Chinese Medical JournalOpen Access

Cancer therapy-induced senescence: A critical yet overlooked aspect

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Authors

JLJingjing LiangLYLu YangRZRuijuan Zhang

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Overview

Observations reveal that therapy-induced senescence promotes chemoresistance in tumors, indicating the need for targeted interventions.

Key Points

  • This research examines the dual role of therapy-induced senescence in cancer treatment and its effects on the tumor microenvironment.
  • Analyzed the impact of antitumor drugs and radiotherapy on cellular senescence and tumor growth.
  • Investigated the role of senescence-associated secretory phenotype in tumor recurrence and immune evasion.
  • Explored the interplay between senescence and the DNA damage response in cancer therapy.
  • Radiotherapy and antitumor drugs induce cellular senescence, contributing to altered tumor microenvironment.
  • Chemoresistance is exacerbated by factors secreted from senescent cells, leading to impaired immune responses.
  • The activation of tumor-suppressor genes such as p53 is linked to senescence, influencing cancer cell proliferation.

Cite This Study

Liang et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff5c83145bc643d1bb51https://doi.org/10.1097/cm9.0000000000004026
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Also Consider

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  1. 1Cellular senescence in cancer immunology and potential therapeutic strategy2026
  2. 2Cellular senescence in cancer: molecular mechanisms and therapeutic targets2024 · 41 citations
  3. 3Therapy-Induced Senescence in Cancer Treatment Resistance: Mechanisms, Evidence, and Translational Opportunities2026
  4. 4Therapy-induced cellular senescence: Potentiating tumor elimination or driving cancer resistance and recurrence?2024 · 14 citations
  5. 5The Implications of Radiotherapy-Induced Cellular Senescence for Cancer Treatment and Tumor Microenvironment Modulation2026 · 3 citations