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April 7, 2026International Journal of Biological SciencesOpen Access

The Implications of Radiotherapy-Induced Cellular Senescence for Cancer Treatment and Tumor Microenvironment Modulation

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Authors

CJChao JiangZTZhouting TuoDWDilinaer Wusiman

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Overview

This review evaluates how radiotherapy-induced cellular senescence affects tumor microenvironment and treatment outcomes, suggesting implications for cancer therapy.

Key Points

  • To explore the relationship between radiotherapy-induced cellular senescence and its effects on tumor behavior and treatment implications.
  • Reviewed key pathways linking radiation injury to cellular senescence.
  • Analyzed the effects of the senescence-associated secretory phenotype (SASP) on the tumor microenvironment.
  • Evaluated emerging therapeutic strategies to target senescence and its consequences.
  • Early senescence enhances immune response and limits tumor growth.
  • Persistent senescence can lead to tumor recurrence and resistance to therapy due to chronic SASP signaling.
  • Emerging treatments like senolytics and immunotherapy show promise in managing senescence-related challenges.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69d49f6bb33cc4c35a227dbchttps://doi.org/10.7150/ijbs.130683
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cancer therapy-induced senescence: A critical yet overlooked aspect2026
  2. 2Therapy-Induced Senescence in Cancer Treatment Resistance: Mechanisms, Evidence, and Translational Opportunities2026
  3. 3Therapy-induced cellular senescence: Potentiating tumor elimination or driving cancer resistance and recurrence?2024 · 14 citations
  4. 4Cellular senescence in cancer immunology and potential therapeutic strategy2026 · 1 citations
  5. 5The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment2025 · 7 citations