Amygdalin-Doped Biopolymer Composites as Potential Wound Dressing Films: In Vitro Study on E. coli and S. aureus

Biopolymer films doped with active substances may become a promising alternative to traditional dressings for skin wounds, as they can deliver drugs while maintaining wound moisture, thus contributing to the healing process. This article describes the preparation of amygdalin-doped biopolymer films for in vitro testing against the bacterial strains typical of chronic wounds: E. coli and S. aureus. Thus, FTIR characterization suggests minimal chemical interaction between amygdalin and the biopolymer matrix components, indicating potential compatibility, while thermogravimetric analysis highlights the thermal behavior of the films as well as the influence of the polymer matrix composition on the amount of bound water and the shift of Tpeak value for the decomposition process of the base polymer. Moreover, the identity of the secondary biopolymer (gelatin or CMC) significantly influences film morphology and antibacterial performance.