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September 10, 2025Journal of Clinical MedicineOpen Access

Influence of Remimazolam and Propofol on Intraoperative Motor Evoked Potentials During Spinal Surgery: A Randomized Crossover Trial

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Authors

BKBo Rim KimHKHye-Bin KimMKMoo Soo Kim

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Overview

Randomized crossover trial comparing remimazolam and propofol on motor evoked potentials, suggesting remimazolam may perform favorably.

Key Points

  • Remimazolam caused less depression in motor evoked potentials compared to propofol during surgery.
  • Propofol's mean amplitude was significantly lower at 635.3 μV compared to remimazolam's 738.4 μV with p = 0.047.
  • In a crossover trial with 18 patients, anesthesia was alternated between propofol and remimazolam to assess effects on MEP.
  • These results indicate remimazolam may provide comparable or superior MEP outcomes, warranting further investigation.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e999bhttps://doi.org/10.3390/jcm14155491
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of remazolam and propofol on intraoperative neurophysiological monitoring during spinal surgery: A prospective randomized study2025
  2. 2Effect of Remimazolam- versus Propofol-Based Total Intravenous General Anesthesia on Intraoperative Hemodynamic Stability for Major Spine Surgery in the Prone Position: A Randomized Controlled Trial2024 · 15 citations
  3. 3Effect of Remimazolam on Transcranial Electrical Motor-evoked Potential in Spine Surgery: A Prospective, Preliminary, Dose-escalation Study2024 · 1 citations
  4. 4Remimazolam Versus Propofol for Anesthesia in Intracranial Neurosurgeries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2026
  5. 5Quality of Postoperative Recovery in Total Intravenous Anesthesia between Remimazolam and Propofol for Intraoperative Neurophysiological Monitoring: A Prospective Double-Blind Randomized Controlled Trial2024 · 11 citations