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September 16, 2025MedicineOpen Access

Influence of remazolam and propofol on intraoperative neurophysiological monitoring during spinal surgery: A prospective randomized study

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Authors

YZYing ZhouHLHaifang LiYLYanping Li

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Overview

Prospective randomized study compares remazolam and propofol during intraoperative neurophysiological monitoring, highlighting significant differences in IONM signals.

Key Points

  • Significantly higher somatosensory and motor evoked potential amplitudes were observed in the remazolam group.
  • Heart rate and mean arterial pressure remained more stable in the remazolam group versus propofol.
  • Latency of neurophysiological signals was shorter in the remazolam group, enhancing monitoring efficacy.
  • Lower remifentanil dosages were needed in the remazolam group, contributing to improved patient outcomes.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4539531b076d99fa593a5https://doi.org/10.1097/md.0000000000043943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quality of Postoperative Recovery in Total Intravenous Anesthesia between Remimazolam and Propofol for Intraoperative Neurophysiological Monitoring: A Prospective Double-Blind Randomized Controlled Trial2024 · 11 citations
  2. 2Influence of Remimazolam and Propofol on Intraoperative Motor Evoked Potentials During Spinal Surgery: A Randomized Crossover Trial2025
  3. 3Remimazolam Versus Propofol for Anesthesia in Intracranial Neurosurgeries: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2026
  4. 4Effect of Remimazolam- versus Propofol-Based Total Intravenous General Anesthesia on Intraoperative Hemodynamic Stability for Major Spine Surgery in the Prone Position: A Randomized Controlled Trial2024 · 15 citations
  5. 5Prospective Randomized Controlled Trial Comparing Anesthetic Management With Remimazolam Besylate and Flumazenil Versus Propofol During Awake Craniotomy Following an Asleep-awake-asleep Method2024 · 15 citations