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September 10, 2025Frontiers in OncologyOpen Access

Risk factors of pathologic complete response for neoadjuvant chemoradiotherapy in locally advanced rectal cancer

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Authors

LZLiangjing ZhouGCGaoyang CaoLSLiming Shi

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Overview

Retrospective analysis identifies key factors impacting pathologic complete response in locally advanced rectal cancer patients after nCRT, highlighting potential for individualized treatment planning.

Key Points

  • Significant predictors of pathologic complete response were identified, including histology, CEA levels, and NLR, improving treatment personalization.
  • The study involved 285 locally advanced rectal cancer patients and utilized retrospective data and logistic regression analysis to determine predictive factors.
  • A nomogram was developed based on multiple significant factors, achieving an AUC of 0.786 for predicting pathologic complete response effectiveness.
  • These findings emphasize the importance of clinical factors in guiding neoadjuvant chemoradiotherapy treatment decisions, contributing to improved outcomes.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e9bcehttps://doi.org/10.3389/fonc.2025.1483065
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in predictive factors for pathological complete response after neoadjuvant therapy in locally advanced rectal cancer2026
  2. 2Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer2024 · 12 citations
  3. 3Predictive value of flexible proctosigmoidoscopy and laboratory findings for complete clinical responses after neoadjuvant chemoradiotherapy in patients with locally advanced primary rectal cancer: a retrospective cohort study2024 · 1 citations
  4. 4A dynamic nomogram for predicting pathologic complete response to neoadjuvant chemotherapy in locally advanced rectal cancer2024 · 2 citations
  5. 5Prediction of pathological complete response and prognosis in locally advanced rectal cancer2024 · 4 citations