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July 23, 2026Radiation OncologyOpen Access

Advances in predictive factors for pathological complete response after neoadjuvant therapy in locally advanced rectal cancer

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Authors

XLXin LeiYHYujia HanXWXiaozhou Wang

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Overview

Systematic review identifies predictive factors for response to neoadjuvant therapy in locally advanced rectal cancer, suggesting new strategies for personalized treatment.

Key Points

  • This research aims to identify factors predictive of pathological complete response after neoadjuvant therapy in locally advanced rectal cancer.
  • Conducted a systematic review of literature
  • Synthesized findings across patient characteristics, tumor features, hematological markers, imaging modalities, and molecular biomarkers
  • Emphasized integrating traditional clinical parameters with emerging technologies like radiomics and artificial intelligence
  • Identified that only about 20% of patients achieve pCR after neoadjuvant therapy
  • Highlighted the importance of integrating diverse predictive factors to optimize treatment outcomes
  • Suggests avenues for enhancing personalized treatment strategies and improving survival outcomes

Cite This Study

Lei et al. (2026) studied this question.

synapsesocial.com/papers/6a61aea0faa9903c51169d07https://doi.org/10.1186/s13014-026-02891-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk factors of pathologic complete response for neoadjuvant chemoradiotherapy in locally advanced rectal cancer2025
  2. 2Prediction of pathologic complete response to neoadjuvant chemoradiation in locally advanced rectal cancer2024 · 12 citations
  3. 3Prediction of pathological complete response and prognosis in locally advanced rectal cancer2024 · 4 citations
  4. 4Association of Pathological Complete Response with Long-Term Oncological Outcomes After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer: A Retrospective Analysis of 327 Patients2026
  5. 5Complete pathologic response surrogacy for survival and its predictors in locally advanced rectal cancer: a retrospective cohort study2026