What question did this study set out to answer?

The study aims to assess the link between complete pathologic response (pCR) and survival in locally advanced rectal cancer (LARC).

May 7, 2026International Journal of Colorectal DiseaseOpen Access

Complete pathologic response surrogacy for survival and its predictors in locally advanced rectal cancer: a retrospective cohort study

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Authors

RGReza GhalehtakiTehran University of Medical Sciences RARomina AbyanehTehran University of Medical Sciences SSSamaneh SalarvandImam Khomeini Hospital

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Implication

Retrospective cohort study shows neoadjuvant chemoradiation improves survival in rectal cancer, highlighting pCR and carcinoembryonic antigen as vital factors.

Key Points

The study aims to assess the link between complete pathologic response (pCR) and survival in locally advanced rectal cancer (LARC).
Retrospective cohort study of 478 LARC patients from a tertiary cancer center
Patients received neoadjuvant long-course chemoradiation followed by definitive surgery
The association between pCR, disease-free survival (DFS), and overall survival (OS) was analyzed.
5-year OS rates were 90.3% for patients with pCR and 64.1% for those without
5-year DFS rates were 91.8% for patients with pCR and 56% for those without
Adjuvant chemotherapy did not improve DFS or OS in patients without pCR
Clinical N2 and CEA > 5ng/mL independently predicted for pCR.

Cite This Study

Ghalehtaki et al. (2026) studied this question.

synapsesocial.com/papers/69fbe325164b5133a91a25df https://doi.org/10.1007/s00384-026-05142-6

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Implication

Retrospective cohort study shows neoadjuvant chemoradiation improves survival in rectal cancer, highlighting pCR and carcinoembryonic antigen as vital factors.

Complete pathologic response surrogacy for survival and its predictors in locally advanced rectal cancer: a retrospective cohort study

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Implication

Key Points

Cite This Study

Complete pathologic response surrogacy for survival and its predictors in locally advanced rectal cancer: a retrospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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