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September 10, 2025European Journal of Cardio-Thoracic Surgery

Comparative efficacy and safety of neoadjuvant immunochemotherapy versus chemotherapy in locally advanced esophageal squamous cell carcinoma: a dual-center retrospective study

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Authors

QGQi GeCGChenglong GuoYMYong Ma

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Overview

Retrospective study shows that neoadjuvant immunochemotherapy enhances pathological response and survival in LA-ESCC, suggesting it may be preferable to chemotherapy.

Key Points

  • NICT significantly improved rates of pathological complete response (27.47% vs. 13.33%), indicating better treatment efficacy.
  • Disease-free survival was significantly enhanced in the NICT group (p = 0.005), highlighting its potential advantages over conventional treatment.
  • Lower respiratory complication rates were observed in the NICT group (68.13% vs. 80.00%), suggesting better safety profiles.
  • Propensity score matching was applied to ensure balanced cohorts of NICT and NCT for a more accurate comparison.

Cite This Study

Ge et al. (2025) studied this question.

synapsesocial.com/papers/68c1b34d54b1d3bfb60e9c3chttps://doi.org/10.1093/ejcts/ezaf268
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Survival outcomes of neoadjuvant immunochemotherapy versus chemotherapy for locally advanced esophageal squamous cell carcinoma2024 · 6 citations
  2. 2A meta-analysis based on propensity analysis studies comparing neoadjuvant immunochemotherapy and neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma2025
  3. 3Comparative efficacy and safety of neoadjuvant immunochemotherapy, chemoradiotherapy, and chemotherapy in resectable locally advanced esophageal squamous cell carcinoma: A network meta-analysis of randomized controlled trials.2026
  4. 4Neoadjuvant immunochemotherapy versus neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for resectable esophageal squamous cell carcinoma: a clinical retrospective study2025 · 6 citations
  5. 5Efficacy of neoadjuvant chemoimmunotherapy in locally advanced resectable esophageal cancer2025 · 1 citations