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October 10, 2025Discover OncologyOpen Access

A meta-analysis based on propensity analysis studies comparing neoadjuvant immunochemotherapy and neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma

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Authors

ZJZixian JinJZJiani ZhuJZJian Zhang

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Overview

Meta-analysis reveals neoadjuvant immunochemotherapy improves overall survival in ESCC patients, suggesting a shift in treatment approach.

Key Points

  • Neoadjuvant immunochemotherapy demonstrated significant overall survival improvements compared to chemoradiotherapy in esophageal squamous cell carcinoma.
  • The analysis of 11 studies with 4,684 patients showed a hazard ratio of 0.61 for overall survival favoring immunochemotherapy.
  • A propensity score analysis compared the two neoadjuvant approaches, focusing on primary outcomes like disease-free survival and pathological response rates.
  • While immunochemotherapy provided better survival rates, the rates for pathological complete response and major pathological response were lower than chemoradiotherapy.

Cite This Study

Jin et al. (2025) studied this question.

synapsesocial.com/papers/68e9435d2d5336d28fb28974https://doi.org/10.1007/s12672-025-03607-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neoadjuvant immunochemotherapy versus neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for resectable esophageal squamous cell carcinoma: a clinical retrospective study2025 · 6 citations
  2. 2Survival outcomes of neoadjuvant immunochemotherapy versus chemotherapy for locally advanced esophageal squamous cell carcinoma2024 · 6 citations
  3. 3Comparative efficacy and safety of neoadjuvant immunochemotherapy, chemoradiotherapy, and chemotherapy in resectable locally advanced esophageal squamous cell carcinoma: A network meta-analysis of randomized controlled trials.2026
  4. 4Comparative efficacy and safety of neoadjuvant immunochemotherapy versus chemotherapy in locally advanced esophageal squamous cell carcinoma: a dual-center retrospective study2025 · 6 citations
  5. 5Comparison of Pathologic Response and Survival Outcomes between Neoadjuvant Chemoradiotherapy (nCRT) and Neoadjuvant Immunochemotherapy (nICT) in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis2024