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September 10, 2025International Journal of Research in Pharmacology & Pharmacotherapeutics

Notch Signalling in Liver Disease: A Comprehensive Analysis

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Authors

KBKeerthi BirudarajuDRDasari RajeshCAChennaboina Soumya Chennuri Akshitha

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Overview

Comprehensive analysis reveals Notch signaling's influence on liver diseases, suggesting novel therapeutic avenues. Highlights include cholangiopathies and hepatocellular carcinoma.

Key Points

  • Aberrant notch signaling contributes to the progression of various liver diseases, including NAFLD and HCC.
  • Notch modulation has the potential to improve disease management in hepatic disorders.
  • Therapies targeting notch, like γ-secretase inhibitors, show promise but face challenges like toxicity.
  • This analysis underscores the need for context-specific interventions to enhance patient outcomes in liver disease.

Cite This Study

Birudaraju et al. (2025) studied this question.

synapsesocial.com/papers/68c1b35954b1d3bfb60ea1f3https://doi.org/10.61096/ijrpp.v14.iss1.2025.16-24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Notch signaling in liver diseases: mechanistic insights and therapeutic implications2026 · 2 citations
  2. 2Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF22025
  3. 3Notch signaling in cancer: metabolic reprogramming and therapeutic implications2025 · 9 citations
  4. 4Notch Signaling: An Emerging Paradigm in the Pathogenesis of Reproductive Disorders and Diverse Pathological Conditions2024 · 19 citations
  5. 5Notch Signaling in Ischemic Damage and Fibrosis: Evidence and Clues from the Heart2017 · 48 citations