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September 10, 2025Journal of Experimental & Clinical Cancer ResearchOpen Access

Targeting NOTCH1-KEAP1 axis retards chronic liver injury and liver cancer progression via regulating stabilization of NRF2

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Authors

CCChunxiao ChangMWMeng WangJLJia Li

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Overview

Observational analysis reveals targeting the NOTCH1 signaling pathway reduces liver damage in HCC patients, indicating its role in NRF2 regulation.

Key Points

  • Targeting NOTCH1 may reduce liver injury and slow cancer progression in chronic liver diseases.
  • NOTCH1 exhibited abnormal elevation in liver cells from chronic liver injury patients, highlighting its potential role.
  • The study shows NOTCH1 interacts with KEAP1, reducing NRF2 stability, which could impact liver health.
  • Targeting the NOTCH1-KEAP1 interaction might offer new therapies for managing chronic liver injury.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3254b1d3bfb60ee4f5https://doi.org/10.1186/s13046-025-03488-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Notch Signalling in Liver Disease: A Comprehensive Analysis2025
  2. 2Notch signaling in liver diseases: mechanistic insights and therapeutic implications2026 · 2 citations
  3. 3WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma2024 · 9 citations
  4. 4Data from WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma2024
  5. 5Notch1 Inhibition Exacerbates APAP-Induced Liver Injury via β-Catenin and Macrophage Polarization2025