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September 10, 2025International Journal of Research in Pharmacology & Pharmacotherapeutics

Exploring the Adaptogenic Power of Withania somnifera: Mechanisms of Stress Alleviation and Implications for Mental Health and Wellness

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Authors

GMG. MamathaNANisha AravindPKP Krishna

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Overview

This review uncovers withania somnifera's adaptogenic effects in stress alleviation, indicating its evolving role in mental health management.

Key Points

  • Withania somnifera significantly reduces cortisol levels and alleviates anxiety, supporting mental health.
  • Clinical evidence shows its efficacy in improving cognitive function and reducing symptoms of depression.
  • The adaptogen's effects are mediated through the regulation of the hypothalamic-pituitary-adrenal axis and neurotransmitter pathways.
  • Ongoing challenges in standardizing formulations highlight the need for further research on optimal dosages.

Cite This Study

Mamatha et al. (2025) studied this question.

synapsesocial.com/papers/68c1b35954b1d3bfb60ea205https://doi.org/10.61096/ijrpp.v14.iss1.2025.139-145
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the therapeutic potential of Ashwagandha (Withania somnifera) supplementation in alleviating stress and stress-related disorders2024 · 5 citations
  2. 2Ashwagandha as an Adaptogen: Its Influence on Sleep Patterns, Stress Response, and Anxiety in Modern Life2024 · 10 citations
  3. 3Nutraceutical Applications of Withania somnifera: The Scientific Knowledge for Rational Modern Use of the “Ayurvedic Adaptogen”2026
  4. 4THE NEUROENDOCRINOLOGY OF CHRONIC STRESS: EVALUATING THE CLINICAL EFFICACY OF ASHWAGANDHA (WITHANIA SOMNIFERA) ON SERUM CORTISOL AND PSYCHOSOCIAL WELL-BEING2026
  5. 5The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects—A Review2026