Metoprolol Succinate Loaded Raft Forming Films for A Gastroretention Drug Delivery System Design and In-Vitro Evaluation

Metoprolol succinate gastro-retentive floating films are being developed and evaluated in this study. When a drug is completely released from its dosage form, metoprolol succinate GRDDS is intended to prolong its stay in the stomach or upper gastrointestinal tract (GIT). A polymer solution comprising chitosan and sodium alginate was prepared via the sonication method in order to create raft films. Plasticizers (polyethylene glycol) and preservatives (methyl paraben) were added to the drug-polymer solutions discussed above. An attempt to successfully create gastroretention rafts that form floating films of metoprolol succinate involved the use of polymer solution of sodium alginate and chitosan. Evaluation was done on the polymer's influence in the formulations. The optimal model that will provide a better fit for in-vitro release data was defined using the Korsemeyer-Peppas model, which details the exact mechanism. With high R2 values, this model demonstrated good linearity. The drug release process was determined to be non-Fickianan for all formulations when the value of n fell between >0.5 and <1.0. The floating film drug delivery technology is an enhanced replacement for traditional dosage forms such as tablets, capsules, and liquids. the ideal dosage at the ideal site in the body to generate and maintain a therapeutic concentration that exhibits pharmacological action while causing the fewest number of adverse effects.