Cumulation of Cadmium and Lead in the Body of White Rats at Astaxanthin Introducing Into the Diet

To reduce the accumulation and toxic effect of cadmium and lead on the body of farm animals, it is promising to use feed additives with different mechanisms of action. Due to the fact that in territories with a high content of toxicants, the latter enter the body for a long time or constantly, it is important for a long or constant introduction of such additives. The toxic effect of cadmium and lead is largely associated with the induction of oxidative stress, so the use of antioxidants, one of which is astaxanthin, is of great interest. In a three-month experiment, white male rats of the 1st group received cadmium and lead with their food (5 and 50 μg/kg of food), animals of the 2nd group were simultaneously given astaxanthin (Astapet 10 at a dose of 1 g/kg of food), the 3rd group served as a control and the animals received a normal diet. After 3 months, in animals of the 1st group, the content of cadmium in the kidneys increased 5.5 times, in the liver - 2.6 times, and in the fur – 1.4 times. Significant lead accumulation was noted in the bones (7.9 times compared to the control). The introduction of astapet 10 into the feed did not significantly reduce the accumulation of cadmium and lead in any of the organs.