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September 10, 2025PhytomedicineOpen Access

Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis

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Authors

JCJing ChenLZLu ZhangYCYuyan Chen

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Overview

Observational analysis reveals reduced liver fibrosis in mice via enhanced Christensenella minuta and altered bile acids metabolism, suggesting potential therapeutic implications.

Key Points

  • TQ treatment significantly alleviated liver fibrosis in CCl4-treated mice, indicating its therapeutic potential.
  • A notable increase in Christensenella minuta abundance accompanied TQ treatment, supporting its role in modulating gut microbiota.
  • Activation of the FXR/FGF15 pathway led to decreased bile acids synthesis, showcasing TQ's mechanism of action.
  • Microbiota depletion via antibiotics confirmed the intestinal microbiota's crucial role in TQ's antifibrotic effects.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1b5fe54b1d3bfb60eaba2https://doi.org/10.1016/j.phymed.2025.157108
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