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This study aims to investigate the effects of total flavones of Abelmoschus manihot on liver fibrosis and elucidate the underlying mechanisms.

February 8, 2026Scientific ReportsOpen Access

Integrated metabolomics and 16S rRNA sequencing reveal the mechanism of total flavones of Abelmoschus manihot (L.) Medic against liver fibrosis

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Metabolomics reveals therapeutic effects of total flavones in alleviating liver fibrosis by improving gut microbiota and reducing oxidative stress.

This study aims to investigate the effects of total flavones of Abelmoschus manihot on liver fibrosis and elucidate the underlying mechanisms.
Established a mice model of CCl 4 -induced liver fibrosis.
Assessed liver injury using histopathology and liver function markers (ALT, AST).
Conducted serum untargeted metabolomics via LC-MS/MS and analyzed gut microbiota profiles by 16S rRNA sequencing.
TFA treatment reduced ALT and AST levels by approximately 55% and 40%, respectively.
TFA significantly ameliorated histopathological changes and reduced oxidative stress and inflammation.
Identified 83 differential metabolites linked to glycerophospholipid, tryptophan, and arachidonic acid metabolism.

Li et al. (2026) studied this question.

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Metabolomics reveals therapeutic effects of total flavones in alleviating liver fibrosis by improving gut microbiota and reducing oxidative stress.