Formulation Development and In-Vitro Evaluation of Glycerosomes Containing Mionoxidil for Topical Application

Background and Objective: Novel vesicular systems provide an alternative to improve drug delivery into and through the skin. Glycerosomal vesicles have shown their ability to increase dermal drug delivery. More over, glycerosomes offer a promising avenue to fulfill the need for a transdermal drug delivery system, can act as drug containing reservoir and the modification of the vesicular compositions or surface properties can adjust the drug release rate and the affinity for the target site. Androgenetic alopecia is the most common form of alopecia in men and women. Topical minoxidil (ROGAINE 2%) became first FDA-approved medication for stimulating hair growth. In the present study an attempt has been made to improve the skin penetration of minoxidil by encapsulating it in Glycerosomes.