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This work evaluates a novel minoxidil formulation to enhance skin permeation and contact time, suggesting improved topical applications.
The delivery of minoxidil using conventional topical solutions suffers from short contact time with the scalp, poor drug penetration, and high dose requirements. This work aimed to prepare an o/w nanoemulsion-based gel of minoxidil with the goal to prolong contact time with the scalp and possibly enhancing skin permeation. Clove oil was selected as an oil phase, Tween® 80 was selected as surfactant and ethanol was selected as a co-surfactant, and distilled water was used as an aqueous phase while propylene glycol (PG) was used as the co-solvent.
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Al-Taiea et al. (2024) studied this question.
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