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September 10, 2025Journal of InfectionOpen Access

Evolutionary dynamics of HRSV following the implementation of nirsevimab immunoprophylaxis in Catalonia (2023-2024)

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Authors

AGAlejandra Gónzalez‐SánchezCACristina AndrésIPIgnasi Prats‐Méndez

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Overview

Observational analysis assesses viral mutations in HRSV following nirsevimab immunoprophylaxis, indicating potential shifts in evolution.

Key Points

  • Nirsevimab immunisation may influence HRSV evolution, particularly in HRSV-B strains.
  • A total of 251 whole-genome sequences and 27 F gene sequences were obtained from non-immunised patients.
  • Selection pressure indicated a shift toward neutral evolution in immunised samples compared to non-immunised.
  • Genomic surveillance is crucial for early detection of mAb-resistant mutants in HRSV.

Cite This Study

Gónzalez‐Sánchez et al. (2025) studied this question.

synapsesocial.com/papers/68c1b60654b1d3bfb60eb0d2https://doi.org/10.1016/j.jinf.2025.106567
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Also Consider

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  4. 4Development and Validation of a New Set of Primers for Identification of Circulating Lineages and Palivizumab/Nirsevimab Resistance in HRSV Isolates from Cabo Verde2025
  5. 5Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France2026 · 6 citations