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September 10, 2025Journal of Multidisciplinary HealthcareOpen Access

Nonlinear Association Between Red Cell Distribution Width-to-Albumin Ratio and Retinopathy: A Cross-Sectional Study

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Authors

JGJinjin GuJiangsu UniversitySQShanhu QiuZhongda Hospital Southeast UniversityZSZilin SunFoshan University

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Implication

Cross-sectional study reveals a nonlinear association between red cell distribution width-to-albumin ratio and retinopathy, suggesting its potential as a clinical risk tool.

Key Points

  • A nonlinear association shows higher odds of retinopathy with increasing red cell distribution width-to-albumin ratio, indicating implications for diabetes care.
  • The study identified an inflection point at a ratio of 3.14, where lower values correlated with significantly increased retinopathy odds (OR = 3.69).
  • Generalized additive models and two-piecewise linear regression were used to evaluate associations between the ratio and retinopathy across a diverse adult population.
  • This finding supports the use of red cell distribution width-to-albumin ratio as a potential tool for risk stratification in public health settings, particularly for diabetic patients.

Cite This Study

Gu et al. (2025) studied this question.

synapsesocial.com/papers/68c1b61454b1d3bfb60eb791https://doi.org/10.2147/jmdh.s530939
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