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A Rare Case of Severe Skin Reaction to Mycophenolate Mofetil in Systemic Lupus Erythematosus with Lupus Nephritis

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Case report reveals a maculopapular rash in a young patient with systemic lupus erythematosus, suggesting need for monitoring.

Severe maculopapular rash developed within 24 hours after starting mycophenolate mofetil, leading to steroid treatment.
The case involved a 13-year-old girl with systemic lupus erythematosus and stage IV lupus nephritis, emphasizing the potential risks of MMF.
Diagnosis of drug-induced eruption was supported by symptom resolution upon discontinuation of MMF and steroid administration.
This report highlights the rare adverse effects of mycophenolate mofetil in patients with lupus, underlining importance of patient monitoring.

Rubiya et al. (2025) studied this question.

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