Uncontrolled Asthma with Hypereosinophilia

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease characterized by asthma, necrotizing vasculitis, extravascular granulomas, and blood and tissue eosinophilia. EGPA progresses through prodromic, eosinophilic, and vasculitic phases. These phases often overlap and sometimes do not progress in the expected sequence. A diagnosis of EGPA should be considered in patients who present with asthma, chronic rhinosinusitis, and eosinophilia, especially when evidence of end-organ involvement such as peripheral neuropathy, lung infiltrates, cardiomyopathy, or issues affecting the skin, gastrointestinal tract, or kidneys is present.