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September 10, 2025Discover OncologyOpen Access

The role of cellular heterogeneity in thyroid cancer: a multi-modal analysis approach with Mendelian randomization

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Authors

YQYichun QianWCWei ChenXCXinyuan Chen

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Overview

Multi-modal analysis explores the connection between inflammatory protein genes and thyroid cancer, suggesting new risk factors.

Key Points

  • Findings reveal significant causal links between AXIN1 expression and thyroid cancer risk, enhancing understanding of genetic influences.
  • Mendelian randomization showed protective effects of ADA_ADA on thyroid cancer, underscoring the role of inflammatory genes.
  • Single-cell RNA sequencing identified six major cell types in the thyroid cancer microenvironment, providing insight into cellular composition.
  • Pseudotime analysis highlighted multiple differentiation trajectories, revealing complex developmental states in thyroid cancer cells.

Cite This Study

Qian et al. (2025) studied this question.

synapsesocial.com/papers/68c1b81854b1d3bfb60ec40fhttps://doi.org/10.1007/s12672-025-03348-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis2025
  2. 2Comprehensive single-cell RNA analysis reveals intertumoral microenvironment heterogeneity and hub niche of carcinogenesis in thyroid cancer2025 · 5 citations
  3. 3Causal role of immune cells in thyroid cancer: a bidirectional Mendelian randomization study2024 · 1 citations
  4. 4Combining single cell and bulk transcriptomics with Mendelian randomization identifies gut microbiota related prognostic genes and mechanisms in thyroid cancer2026
  5. 5Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases2026 · 5 citations