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September 5, 2025Discover OncologyOpen Access

Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis

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Authors

LJLi JiangCapital UniversityTZTingting ZhangAnhui Medical UniversityJHJihua Han

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Implication

Mendelian randomization reveals inflammatory cytokines related to thyroid cancer risk, suggesting new biomarkers.

Key Points

  • Causal roles of inflammatory cytokines in thyroid cancer were identified using genetic data and MR analysis.
  • Analysis found that IL-1RA and B-NGF increase thyroid cancer risk, while M-CSF appears protective.
  • Mendelian randomization with genetic instrumental variables was applied to assess causal relationships among factors.
  • Findings highlight potential biomarkers for thyroid cancer management and inform precision medicine strategies.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02d7fhttps://doi.org/10.1007/s12672-025-03533-9
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study2017 · 54 citations
  2. 2Thyroid cancer incidence trend and association with obesity, physical activity in the United States2022 · 14 citations