This approach demonstrates the efficient formation of multiple C-N and Csp-Csp bonds in benzimidazoles, suggesting novel synthetic pathways.
We report the simple synthesis of 1,2-disubstituted benzimidazoles using three versatile building blocks: benzaldehydes, o-phenylenediamines, and phenylpropiolic acid. The protocol facilitates the formation of three C-N bonds and one Csp-Csp bond in a one-pot reaction and yields novel products that have not been previously synthesized.
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Mohaghegh et al. (2025) studied this question.
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