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September 10, 2025EpidemicsOpen Access

Explaining the stable coexistence of drug-resistant and -susceptible pathogens: the Resistance Acquisition Purifying Selection model

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Authors

PPPleuni S. Pennings

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Overview

Mathematical model describes the coexistence of resistant and susceptible strains in pathogens, indicating key factors like drug usage and strain diversity.

Key Points

  • The model predicts stable coexistence of resistant and susceptible strains under certain conditions.
  • Resistance levels depend on population-level drug usage and include multiple genetic backgrounds.
  • New resistant strains continuously appear and disappear due to mutation and horizontal gene transfer.
  • Data from a longitudinal study on E. coli supports the model's predictions about resistance dynamics.

Cite This Study

Pleuni S. Pennings (2025) studied this question.

synapsesocial.com/papers/68c1b81f54b1d3bfb60ec72ahttps://doi.org/10.1016/j.epidem.2025.100848
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