What question did this study set out to answer?

To determine whether maintaining drug-sensitive bacterial populations via adaptive antibiotic dosing can delay treatment failure by competitively suppressing drug-resistant pathogens.

May 15, 2020PLoS BiologyOpen Access

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

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Authors

EHElsa Hansen JKJason Karslake RWRobert J. Woods

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Overview

In vitro experimental study demonstrates that maintaining sensitive bacterial populations delays drug-resistant Escherichia coli expansion, suggesting competitive suppression improves antibiotic...

Key Points

To determine whether maintaining drug-sensitive bacterial populations via adaptive antibiotic dosing can delay treatment failure by competitively suppressing drug-resistant pathogens.
Conducted continuous culture experiments in computer-controlled bioreactors combined with mathematical modeling to evaluate bacterial population dynamics.
Measured the escape time required for drug-resistant Escherichia coli to surpass an acceptable threshold density under adaptive antibiotic dosing, comparing resistant-only cultures to cultures containing sensitive cells.
Bacterial populations containing only resistant cells rapidly breached the threshold density, whereas populations co-containing maximum tolerable levels of sensitive cells were contained for significantly longer durations.
Prolongation of resistance escape time occurred only when the threshold density was sufficiently high, confirming mathematical predictions that competitive suppression requires substantial sensitive cell burdens.

Cite This Study

Hansen et al. (2020) studied this question.

synapsesocial.com/papers/6a8b1deede5ec4e001e3b868 https://doi.org/10.1371/journal.pbio.3000713

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May 15, 2020PLoS BiologyOpen Access

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

View Full Paper

Ask AI

Bookmark

Authors

EHElsa Hansen JKJason Karslake RWRobert J. Woods

Discussion

Member takes

Overview

In vitro experimental study demonstrates that maintaining sensitive bacterial populations delays drug-resistant Escherichia coli expansion, suggesting competitive suppression improves antibiotic...

Key Points

To determine whether maintaining drug-sensitive bacterial populations via adaptive antibiotic dosing can delay treatment failure by competitively suppressing drug-resistant pathogens.
Conducted continuous culture experiments in computer-controlled bioreactors combined with mathematical modeling to evaluate bacterial population dynamics.
Measured the escape time required for drug-resistant Escherichia coli to surpass an acceptable threshold density under adaptive antibiotic dosing, comparing resistant-only cultures to cultures containing sensitive cells.
Bacterial populations containing only resistant cells rapidly breached the threshold density, whereas populations co-containing maximum tolerable levels of sensitive cells were contained for significantly longer durations.
Prolongation of resistance escape time occurred only when the threshold density was sufficiently high, confirming mathematical predictions that competitive suppression requires substantial sensitive cell burdens.

Cite This Study

Hansen et al. (2020) studied this question.

synapsesocial.com/papers/6a8b1deede5ec4e001e3b868 https://doi.org/10.1371/journal.pbio.3000713

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