What question did this study set out to answer?

To investigate how population-level interactions and the timing of drug exposure govern the survival or collapse of bacterial communities harboring drug-resistant subpopulations.

September 12, 2019Open Access

Delayed antibiotic exposure induces population collapse in enterococcal communities with drug-resistant subpopulations

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Authors

KHKelsey M. Hallinen JKJason Karslake KWKevin B. Wood

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Overview

In vitro study reveals delayed antibiotic influx triggers population collapse in mixed Enterococcus faecalis communities, highlighting counterintuitive density-dependent dynamics.

Key Points

To investigate how population-level interactions and the timing of drug exposure govern the survival or collapse of bacterial communities harboring drug-resistant subpopulations.
Coupled mathematical models of density-dependent growth feedback with continuous-culture experiments in computer-controlled bioreactors.
Evaluated mixed Enterococcus faecalis communities composed of drug-sensitive cells and drug-resistant, beta-lactamase-producing subpopulations under immediate versus delayed antibiotic dosing regimens.
Bacterial communities exhibited competing density-dependent dynamics, displaying population survival, collapse, or bistable behaviors where survival depended on initial population size.
Drug-sensitive cell growth increased drug inhibition, while resistant cell growth reduced effective inhibition via beta-lactamase production.
Identical populations exposed to delayed drug influx collapsed under lower average antibiotic concentrations, whereas populations exposed to immediate drug influx survived.

Cite This Study

Hallinen et al. (2019) studied this question.

synapsesocial.com/papers/6a6f3c8aa528af2d65c2e3a2 https://doi.org/10.1101/766691

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September 12, 2019Open Access

Delayed antibiotic exposure induces population collapse in enterococcal communities with drug-resistant subpopulations

View Full Paper

Ask AI

Bookmark

Authors

KHKelsey M. Hallinen JKJason Karslake KWKevin B. Wood

Discussion

Member takes

Overview

In vitro study reveals delayed antibiotic influx triggers population collapse in mixed Enterococcus faecalis communities, highlighting counterintuitive density-dependent dynamics.

Key Points

To investigate how population-level interactions and the timing of drug exposure govern the survival or collapse of bacterial communities harboring drug-resistant subpopulations.
Coupled mathematical models of density-dependent growth feedback with continuous-culture experiments in computer-controlled bioreactors.
Evaluated mixed Enterococcus faecalis communities composed of drug-sensitive cells and drug-resistant, beta-lactamase-producing subpopulations under immediate versus delayed antibiotic dosing regimens.
Bacterial communities exhibited competing density-dependent dynamics, displaying population survival, collapse, or bistable behaviors where survival depended on initial population size.
Drug-sensitive cell growth increased drug inhibition, while resistant cell growth reduced effective inhibition via beta-lactamase production.
Identical populations exposed to delayed drug influx collapsed under lower average antibiotic concentrations, whereas populations exposed to immediate drug influx survived.

Cite This Study

Hallinen et al. (2019) studied this question.

synapsesocial.com/papers/6a6f3c8aa528af2d65c2e3a2 https://doi.org/10.1101/766691

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